Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80645
Title: An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
Authors: Chen, H
Cheng, R
Zhao, X 
Zhang, Y
Tam, A 
Yan, Y
Shen, H
Zhang, YS
Qi, J
Feng, Y
Liu, L
Pan, G
Cui, W
Deng, L
Issue Date: 2019
Publisher: Nature Publishing Group
Source: NPG Asia materials, 2019, v. 11, no. 1, 3 How to cite?
Journal: NPG Asia materials 
Abstract: We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.
URI: http://hdl.handle.net/10397/80645
ISSN: 1884-4049
EISSN: 1884-4057
DOI: 10.1038/s41427-018-0103-9
Rights: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
The following publication Chen, H., Cheng, R., Zhao, X., Zhang, Y., Tam, A., Yan, Y., ... & Liu, L. (2019). An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair. NPG Asia Materials, 11(1), 3 is available at https://doi.org/10.1038/s41427-018-0103-9
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