Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8034
Title: The genetic and environmental factors for keratoconus
Authors: Gordon-Shaag, A
Millodot, M
Shneor, E
Liu, Y
Issue Date: 2015
Publisher: Hindawi Publishing Corporation
Source: BioMed research international, 2015, v. 2015, 795738 How to cite?
Journal: BioMed research international 
Abstract: Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its pathogenesis. This review is to summarize the current research development in KC epidemiology and genetic etiology. Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography. Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses. A number of genes have been discovered at a relatively rapid pace. The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies.
URI: http://hdl.handle.net/10397/8034
ISSN: 2314-6133
EISSN: 2314-6141
DOI: 10.1155/2015/795738
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