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http://hdl.handle.net/10397/8034
Title: | The genetic and environmental factors for keratoconus | Authors: | Gordon-Shaag, A Millodot, M Shneor, E Liu, Y |
Issue Date: | 2015 | Source: | BioMed research international, 2015, v. 2015, 795738 | Abstract: | Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its pathogenesis. This review is to summarize the current research development in KC epidemiology and genetic etiology. Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography. Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses. A number of genes have been discovered at a relatively rapid pace. The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies. | Publisher: | Hindawi Publishing Corporation | Journal: | BioMed research international | ISSN: | 2314-6133 | EISSN: | 2314-6141 | DOI: | 10.1155/2015/795738 | Rights: | Copyright © 2015 Ariela Gordon-Shaag et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The following article: Gordon-Shaag, A., Millodot, M., Shneor, E., & Liu, Y. (2015). The genetic and environmental factors for keratoconus. BioMed research international, 2015, v. 2015, 795738 is available at https://doi.org/10.1155/2015/795738. |
Appears in Collections: | Journal/Magazine Article |
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Gordon-Shaag_Genetic_Environmental_Factors.pdf | 1.34 MB | Adobe PDF | View/Open |
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