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Title: High myopia induced by form deprivation is associated with altered corneal biomechanical properties in chicks
Authors: Kang, BS 
Wang, LK 
Zheng, YP 
Guggenheim, JA
Stell, WK
Kee, CS 
Issue Date: 2018
Publisher: Public Library of Science
Source: PLoS one, Nov. 2018, v. 13, no. 11, e0207189, p. 1-17 How to cite?
Journal: PLoS oneonline only 
Abstract: The cornea is a soft, transparent, composite organic tissue, which forms the anterior outer coat of the eyeball. Although high myopia is increasing in prevalence worldwide and is known to alter the structure and biomechanical properties of the sclera, remarkably little is known about its impact on the biomechanics of the cornea. We developed and validated a novel optical-coherence-tomography-indentation probe-to measure corneal biomechanical properties in situ, in chicks having experimentally-induced high myopia, while maintaining intraocular pressure at levels covering the physiological range. We found that the cornea of highly myopic chicks was more steeply curved and softer, at all tested intraocular pressures, than that in contralateral, non-myopic eyes, or in age-matched normal, untreated eyes. These results indicate that the biomechanical properties of the cornea are altered in chicks developing experimentally-induced myopia.
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0207189
Rights: © 2018 Kang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication Kang, B.S., Wang, L.K., Zheng, Y.P., Guggenheim, J.A., Stell, W.K., & Kee, C.S. (2018). High myopia induced by form deprivation is associated with altered corneal biomechanical properties in chicks. PLoS one, 13 (11), e0207189, p. 1-17 is available at
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