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Title: The in vivo therapeutic effect of free wanderer powder ( xiāo yáo sn, xiaoyaosan) on mice with 4T1 cell induced breast cancer model
Authors: Chen WF 
Xu L 
Yu CH 
Ho CK 
Wu K 
Leung G 
Wong, MS 
Keywords: Free wanderer powder ( xiāo yáo sn
4T1 cells
Breast cancer
Balb/c mice
Issue Date: 2012
Publisher: National Taiwan University
Source: Journal of traditional and complementary medicine, 2012, v. 2, no. 1, p. 67-75 How to cite?
Journal: Journal of traditional and complementary medicine 
Abstract: In the present study, we investigated the therapeutic effect of a classical TCM formula, Free Wanderer Powder ( xiāo yáo sn), in a breast cancer mouse model induced with estrogen-insensitive breast cancer 4T1 cells. Ovariectomized Balb/c mice (6-8 weeks) or sham mice were injected into the fourth mammary fat pad with 4T1 cells in which tumors were palpable 7 days after injection. On the eighth day, the mice were divided into 4 groups and tubefed daily with vehicle, Free Wanderer Powder ( xiāo yáo sn) formula or tamoxifen for 28 days. Tumor growth inhibition and the decrease of the average tumor mass were most evident in mice treated with Free Wanderer Powder ( xiāo yáo sn). Free Wanderer Powder ( xiāo yáo sn) treatment significantly reduced Bcl-2 and elevated Bax and p53 protein expressions in breast cancer tumor. These results were further confirmed by immunohistochemisty. Tamoxifen could decrease spleen mass and Bcl-2 protein expression, increase the Bax protein expression as well as exert uterotrophic effects by increasing uterus index and inducing the gene expressions in the uterus. Taken together, these results show that Free Wanderer Powder ( xiāo yáo sn) treatment induced apoptosis at protein level and inhibited the tumor growth in 4T1-induced ovariectomized Balb/c female mice, indicating the possibility of its future use for treatment of estrogen-insensitive breast caner.
ISSN: 2225-4110
DOI: 10.1016/S2225-4110(16)30073-6
Rights: Copyright © 2011 Committee on Chinese Medicine and Pharmacy, Taiwan. This is an open access article under the CC BY-NC-ND license (
The following publication Chen, W. -., Xu, L., Yu, C. -., Ho, C. -., Wu, K., Leung, G., & Wong, M. -. (2012). The in vivo therapeutic effect of free wanderer powder ( xiāo yáo sn, xiaoyaosan) on mice with 4T1 cell induced breast cancer model. Journal of Traditional and Complementary Medicine, 2(1), 67-75 is available at
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