Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80086
Title: Aerobic exercise interacts with neurotrophic factors to predict cognitive functioning in adolescents
Authors: Lee, TMC
Wong, ML
Lau, BWM 
Lee, JCD
Yau, SY
So, KF
Keywords: Cognition
Exercise
Frontal regions
Neurogenesis
Neurotrophic factors
Temporal regions
Issue Date: 2014
Publisher: Pergamon
Source: Psychoneuroendocrinology, 2014, v. 39, no. 1, p. 214-224 How to cite?
Journal: Psychoneuroendocrinology 
Abstract: Recent findings have suggested that aerobic exercise may have a positive effect on brain functioning, in addition to its well-recognized beneficial effects on human physiology. This study confirmed the cognitive effects of aerobic exercise on the human brain. It also examined the relationships between exercise and the serum levels of neurotrophic factors (BDNF, IGI-1, and VEGF). A total of 91 healthy teens who exercised regularly participated in this study. A between-group design was adopted to compare cognitive functioning subserved by the frontal and temporal brain regions and the serum levels of neurotrophic factors between 45 regular exercisers and 46 matched controls. The exercisers performed significantly better than the controls on the frontal and temporal functioning parameters measured. This beneficial cognitive effect was region-specific because no such positive cognitive effect on task-tapping occipital functioning was observed. With respect to the serum levels of the neurotrophic factors, a negative correlation between neurotrophic factors (BDNF and VEGF) with frontal and medial-temporal lobe function was revealed. Furthermore, the levels of BDNF and VEGF interacted with exercise status in predicting frontal and temporal lobe function. This is the first report of the interaction effects of exercise and neurotrophic factors on cognitive functioning. Herein, we report preliminary evidence of the beneficial effects of regular aerobic exercise in improving cognitive functions in teens. These beneficial effects are region-specific and are associated with the serum levels of neurotrophic factors. Our findings lay the path for future studies looking at ways to translate these beneficial effects to therapeutic strategies for adolescents.
URI: http://hdl.handle.net/10397/80086
ISSN: 0306-4530
EISSN: 1873-3360
DOI: 10.1016/j.psyneuen.2013.09.019
Rights: © 2013 The Authors. Published by Elsevier Ltd. Open access under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/3.0/)
The following publication Lee, T. M. C., Wong, M. L., Lau, B. W. M., Lee, J. C. D., Yau, S. -., & So, K. -. (2014). Aerobic exercise interacts with neurotrophic factors to predict cognitive functioning in adolescents. Psychoneuroendocrinology, 39(1), 214-224 is available at https://dx.doi.org/10.1016/j.psyneuen.2013.09.019
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