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|Title:||A quinoline-based FtsZ inhibitor for the study of antimicrobial activity and synergistic effects with β-lactam antibiotics||Authors:||Fang, Z
|Issue Date:||2018||Publisher:||Elsevier||Source:||Journal of pharmacological sciences, 2018, v. 137, no. 3, p. 283-289 How to cite?||Journal:||Journal of pharmacological sciences||Abstract:||The antibacterial activity and the synergistic effect with β-lactam antibiotics of a new 1-methylquinolinium iodide derivative were investigated. The experimental results indicate that the compound possesses a strong antibacterial activity against a panel of bacteria including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and NDM-1 Escherichia coli with the MIC values from 0.75 μg/mL to 6 μg/mL. In addition, this compound combined with β-lactam antibiotics shows strong synergistic antimicrobial activities against antibiotic-resistant strains of S. aureus. The results of biochemical studies also reveal that this compound can effectively disrupt GTPase activity, polymerization of FtsZ, and cell division to cause cell death. The compound shows high potential for further development as a new generation of antibacterial agents to fight against the emergence of multidrug-resistant bacteria.||URI:||http://hdl.handle.net/10397/80029||ISSN:||1347-8613||EISSN:||1347-8648||DOI:||10.1016/j.jphs.2018.07.005||Rights:||© 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
The following publication Fang, Z., Ban, L., Li, Y., Yuan, W., Liu, Z., Liu, T., . . . Yao, X. (2018). A quinoline-based FtsZ inhibitor for the study of antimicrobial activity and synergistic effects with β-lactam antibiotics. Journal of Pharmacological Sciences, 137(3), 283-289 is available at https://dx.doi.org/10.1016/j.jphs.2018.07.005
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