Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79992
Title: A phytochemical-based copolymer derived from coriolus versicolor polysaccharopeptides for gene delivery
Authors: Lai WF 
Lin, MC
Tang, G
Keywords: Coriolus versicolor
Gene delivery
Herbs
Poly(ethylenimine)
Polysaccharopeptide
Issue Date: 2018
Publisher: Molecular Diversity Preservation International (MDPI)
Source: Molecules, 2018, v. 23, no. 9, 2273, p. 1-10 How to cite?
Journal: Molecules 
Abstract: Coriolus versicolor is an herb widely used for cancer treatment in traditional Chinese medicine. Its active ingredients, polysaccharopeptides (PSP), have been used for adjuvant therapies in cancer treatment. This study conjugates Coriolus versicolor PSP with poly(ethylenimine) (PEI) to generate a PSP-PEI copolymer for gene transfer. After PEI conjugation, both the pH buffering capacity and DNA compaction ability of PSP are significantly increased. Compared with that of PSP, the transfection efficiency of PSP-PEI is 10 to 20-fold higher in vitro. This is a proof-of-concept study reporting the direct use of bioactive phytochemicals from traditional Chinese medicine for gene vector development. The promising performance of PSP-PEI raises the possibility that bioactive herbal ingredients can be further developed as a multi-therapeutic gene carrier for tackling cancers.
URI: http://hdl.handle.net/10397/79992
ISSN: 1420-3049
DOI: 10.3390/molecules23092273
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The following publication Lai, W. -., Lin, M. C., & Tang, G. (2018). A phytochemical-based copolymer derived from coriolus versicolor polysaccharopeptides for gene delivery. Molecules, 23(9), 2273, 1-10 is available at https://dx.doi.org/10.3390/molecules23092273
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