Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/79930
Title: Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
Authors: Zhu, LZ 
Ma, WJ
Zhang, MX
Lee, MML 
Wong, WY 
Chan, BD 
Yang, QQ
Wong, WT 
Tai, WCS 
Lee, CS
Issue Date: 2018
Publisher: Nature Publishing Group
Source: Nature communications, 29 Mar. 2018, v. 9, 1283 How to cite?
Journal: Nature communications 
Abstract: Challenges in the development of anti-cancer chemotherapeutics continue to exist, particularly with respect to adverse effects and development of resistance, underlining the need for novel drugs with good safety profiles. Natural products have proven to be a fertile ground for exploitation, and development of anti-cancer drugs from structurally complex natural products holds promise. Unfortunately, this approach is often hindered by low isolation yields and limited information from preliminary cell-based assays. Here we report a concise and scalable synthesis of a series of low-abundance Isodon diterpenoids (a large class of natural products with over 1000 members isolated from the herbs of genus Isodon, which are well-known folk medicines for the treatment of inflammation and cancer), including eriocalyxin B, neolaxiflorin L and xerophilusin I. These scalable syntheses enable multilevel bio-evaluation of the natural products, in which we identify neolaxiflorin L as a promising anti-cancer drug candidate.
URI: http://hdl.handle.net/10397/79930
EISSN: 2041-1723
DOI: 10.1038/s41467-018-03546-9
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