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Title: The relationships between brain structural changes and perceived loneliness in older adults suffering from late-life depression
Authors: Sin, ELL
Liu, HL
Lee, SH
Huang, CM
Wai, YY
Chen, YL
Chan, CCH 
Lin, CM
Lee, TMC
Keywords: Late-life depression
Perceived loneliness
Voxel-based morphometry
Issue Date: 2018
Publisher: John Wiley & Sons
Source: International journal of geriatric psychiatry, Apr. 2018, v. 33, no. 4, p. 606-612 How to cite?
Journal: International journal of geriatric psychiatry 
Abstract: Objective Late-life depression is a significant health risk factor for older adults, part of which is perceived loneliness. In this voxel-based morphometry study, we examined the relationships between perceived loneliness and depression recurrence.
Methods Fifty-two older adults were recruited, and they were split into 3 groups: single episode, multiple episodes, or normal control groups, according to their clinical histories.
Results This result suggests the level of functioning regarding the reward system may be negatively related to the number of depressive episodes. Taken together, the findings of this study offer important insight into the neural underpinnings of the course and chronicity of late-life depression.
ISSN: 0885-6230
EISSN: 1099-1166
DOI: 10.1002/gps.4831
Rights: This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
© 2017 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.
The following publication Sin, E. L. L., Liu, H. L., Lee, S. H., Huang, C. M., Wai, Y. Y., Chen, Y. L., … & Lee, T. M. C. (2018). The relationships between brain structural changes and perceived loneliness in older adults suffering from late-life depression. International Journal of Geriatric Psychiatry, 33(4), 606-612 is available at
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