Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/78844
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Yang, ZL | en_US |
dc.creator | Yang, Y | en_US |
dc.creator | Zhang, L | en_US |
dc.creator | Xiong, KQ | en_US |
dc.creator | Li, XY | en_US |
dc.creator | Zhang, F | en_US |
dc.creator | Wang, J | en_US |
dc.creator | Zhao, X | en_US |
dc.creator | Huang, N | en_US |
dc.date.accessioned | 2018-10-26T01:21:18Z | - |
dc.date.available | 2018-10-26T01:21:18Z | - |
dc.identifier.issn | 0142-9612 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/78844 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2018 Elsevier Ltd. All rights reserved. | en_US |
dc.rights | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.rights | The following publication Yang, Z., Yang, Y., Zhang, L., Xiong, K., Li, X., Zhang, F., ... & Huang, N. (2018). Mussel-inspired catalytic selenocystamine-dopamine coatings for long-term generation of therapeutic gas on cardiovascular stents. Biomaterials, 178, 1-10 is available at https://doi.org/10.1016/j.biomaterials.2018.06.008 | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Selenocystamine | en_US |
dc.subject | Dopamine | en_US |
dc.subject | Cardiovascular stent | en_US |
dc.subject | Surface chemistry | en_US |
dc.title | Mussel-inspired catalytic selenocystamine-dopamine coatings for long-term generation of therapeutic gas on cardiovascular stents | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 10 | en_US |
dc.identifier.volume | 178 | en_US |
dc.identifier.doi | 10.1016/j.biomaterials.2018.06.008 | en_US |
dcterms.abstract | The development of a nitric oxide (NO)-generating surface with long-term, stable and controllable NO release improves the therapeutic efficacy of cardiovascular stents. In this work, we developed a "one-pot" method inspired by mussel adhesive proteins for copolymerization of selenocystamine (SeCA) and dopamine (Dopa) to form a NO-generating coating on a 316 L stainless steel (SS) stent. This "one-pot" method is environmentally friendly and easy to popularize, with many advantages including simple manufacturing procedure, high stability and no involvement of organic solvents. Such SeCA/Dopa coatings also enabled us to develop a catalytic surface for local NO-generation by reaction of endogenously existing S-nitrothiol species from fresh blood. We found that the developed SeCA/Dopa coatings could release NO in a controllable and stable manner for more than 60 days. Additionally, the released NO significantly inhibited smooth muscle cell (SMC) proliferation and migration, as well as platelet activation and aggregation through the up-regulation of cyclic guanosine monophosphate synthesis. Moreover, such NO generation enhanced the adhesion, proliferation and migration of endothelial cells (ECs), and achieved rapid in vivo re-endothelialization, effectively reducing in-stent restenosis and neointimal hyperplasia. We envision that the SeCA/Dopa-coated 316L SS stent could be a promising platform for treatment of cardiovascular diseases. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Biomaterials, Sept. 2018, v. 178, p. 1-10 | en_US |
dcterms.isPartOf | Biomaterials | en_US |
dcterms.issued | 2018 | - |
dc.identifier.isi | WOS:000440959000001 | - |
dc.identifier.pmid | 29902532 | - |
dc.identifier.rosgroupid | 2017004109 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201810 bcrc | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | a0596-n33, BME-0144 | en_US |
dc.identifier.SubFormID | 477 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China; Distinguished Young Scholars of Sichuan Province; Fundamental Research Funds for the Central Universities; Hong Kong Polytechnic University; Fundamental Research Funds for the Central Universities; Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Zhang_Mussel-Inspired_Catalytic_Selenocystamine-Dopamine.pdf | Pre-Published version | 1.5 MB | Adobe PDF | View/Open |
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