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Title: | Inverted activity patterns in ventromedial prefrontal cortex during value-guided decision-making in a less-is-more task | Authors: | Papageorgiou, GK Sallet, J Wittmann, MK Chau, BKH Schüffelgen, U Buckley, MJ Rushworth, MFS |
Issue Date: | 2017 | Source: | Nature communications, 1 Dec. 2017, v. 8, 1886 | Abstract: | Ventromedial prefrontal cortex has been linked to choice evaluation and decision-making in humans but understanding the role it plays is complicated by the fact that little is known about the corresponding area of the macaque brain. We recorded activity in macaques using functional magnetic resonance imaging during two very different value-guided decision-making tasks. In both cases ventromedial prefrontal cortex activity reflected subjective choice values during decision-making just as in humans but the relationship between the blood oxygen level-dependent signal and both decision-making and choice value was inverted and opposite to the relationship seen in humans. In order to test whether the ventromedial prefrontal cortex activity related to choice values is important for decision-making we conducted an additional lesion experiment; lesions that included the same ventromedial prefrontal cortex region disrupted normal subjective evaluation of choices during decision-making. | Publisher: | Nature Publishing Group | Journal: | Nature communications | EISSN: | 2041-1723 | DOI: | 10.1038/s41467-017-01833-5 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2017 The following publication Papageorgiou, G. K., Sallet, J., Wittmann, M. K., Chau, B. K. H., Schüffelgen, U., Buckley, M. J., & Rushworth, M. F. S. (2017). Inverted activity patterns in ventromedial prefrontal cortex during value-guided decision-making in a less-is-more task. Nature Communications, 8(1), 2889 is available at https://doi.org/10.1038/s41467-017-01833-5 |
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