Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/78382
Title: A versatile dynamic mussel-inspired biointerface : from specific cell behavior modulation to selective cell isolation
Authors: Liu, L
Tian, XH
Ma, Y
Duan, YQ
Zhao, X 
Pan, GQ
Keywords: Cell adhesion
Dynamic biointerface
Mussel-inspired peptides
Reversible covalent bonds
Tumor cell capture
Issue Date: 2018
Publisher: Wiley-VCH
Source: Angewandte chemie international edition, 25 June 2018, v. 57, no. 26, p. 7878-7882 How to cite?
Journal: Angewandte chemie international edition 
Abstract: Reported here is a novel dynamic biointerface based on reversible catechol-boronate chemistry. Biomimetically designed peptides with a catechol-containing sequence and a cell-binding sequence at each end were initially obtained. The mussel-inspired peptides were then reversibly bound to a phenylboronic acid (PBA) containing polymer-grafted substrate through sugar-responsive catechol-boronate interactions. The resultant biointerface is thus capable of dynamic presentation of the bioactivity (i.e. the cell-binding sequence) by virtue of changing sugar concentrations in the system (similar to human glycemic volatility). In addition, the sugar-responsive biointerface enables not only dynamic modulation of stem cell adhesion behaviors but also selective isolation of tumor cent Considering the highly biomimetic nature and biological stimuli-responsiveness, this mussel-inspired dynamic biointerface holds great promise in both fundamental cell biology research and advanced medical applications.
URI: http://hdl.handle.net/10397/78382
ISSN: 1433-7851
EISSN: 1521-3773
DOI: 10.1002/anie.201804802
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