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http://hdl.handle.net/10397/78382
Title: | A versatile dynamic mussel-inspired biointerface : from specific cell behavior modulation to selective cell isolation | Authors: | Liu, L Tian, X Ma, Y Duan, Y Zhao, X Pan, G |
Issue Date: | 25-Jun-2018 | Source: | Angewandte chemie international edition, 25 June 2018, v. 57, no. 26, p. 7878-7882 | Abstract: | Reported here is a novel dynamic biointerface based on reversible catechol-boronate chemistry. Biomimetically designed peptides with a catechol-containing sequence and a cell-binding sequence at each end were initially obtained. The mussel-inspired peptides were then reversibly bound to a phenylboronic acid (PBA) containing polymer-grafted substrate through sugar-responsive catechol-boronate interactions. The resultant biointerface is thus capable of dynamic presentation of the bioactivity (i.e. the cell-binding sequence) by virtue of changing sugar concentrations in the system (similar to human glycemic volatility). In addition, the sugar-responsive biointerface enables not only dynamic modulation of stem cell adhesion behaviors but also selective isolation of tumor cent Considering the highly biomimetic nature and biological stimuli-responsiveness, this mussel-inspired dynamic biointerface holds great promise in both fundamental cell biology research and advanced medical applications. | Keywords: | Cell adhesion Dynamic biointerface Mussel-inspired peptides Reversible covalent bonds Tumor cell capture |
Publisher: | Wiley-VCH | Journal: | Angewandte chemie international edition | ISSN: | 1433-7851 | EISSN: | 1521-3773 | DOI: | 10.1002/anie.201804802 | Rights: | © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim This is the peer reviewed version of the following article: Liu, L., Tian, X., Ma, Y., Duan, Y., Zhao, X., & Pan, G. (2018). A Versatile Dynamic Mussel‐Inspired Biointerface: From Specific Cell Behavior Modulation to Selective Cell Isolation. Angewandte Chemie, 130(26), 8004-8008, which has been published in final form at https://doi.org/10.1002/anie.201804802. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
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Zhao_Versatile_Dynamic_Mussel-inspired.pdf | Pre-Published version | 1.1 MB | Adobe PDF | View/Open |
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