Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/77886
Title: Diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy : a systematic review and meta-analysis
Authors: Wang, F
Zhang, J 
Yu, J
Liu, S
Zhang, R
Ma, X
Yang, Y
Wang, P
Issue Date: 2017
Publisher: Hindawi Publishing Corporation
Source: Journal of diabetes research, 2017, v. 2017,8787261 How to cite?
Journal: Journal of diabetes research 
Abstract: Objective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy.
Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy.
Results. A total of 19 comparative trials met the inclusion criteria and were part of the qualitative synthesis. Eight trials using nerve conduction studies as the reference standard were selected for the meta-analysis. The pooled sensitivity and specificity of monofilament tests for detecting diabetic peripheral neuropathy were 0.53 (95% confidence interval (CI) 0.32 to 0.74) and 0.88 (95% CI 0.78 to 0.94), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.56 (95% CI 2.93 to 7.10) and 0.53 (95% CI 0.35 to 0.81), respectively.
Conclusions. Our review indicated that monofilament tests had limited sensitivity for screening diabetic peripheral neuropathy. The clinical use of the monofilament test in the evaluation of diabetic peripheral neuropathy cannot be encouraged based on currently available evidence.
URI: http://hdl.handle.net/10397/77886
ISSN: 2314-6745
EISSN: 2314-6753
DOI: 10.1155/2017/8787261
Rights: Copyright © 2017 Fengyi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Fengyi Wang, Jiaqi Zhang, Jiadan Yu, et al., “Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis,” Journal of Diabetes Research, vol. 2017, Article ID 8787261, 12 pages, 2017 is available at https://doi.org/10.1155/2017/8787261.
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