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Title: Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media
Authors: Yu, Z 
Huangfu, J
Zhao, F
Xia, M
Wu, X
Niu, X
Li, D
Lai, P 
Wang, D
Issue Date: 2018
Publisher: Nature Publishing Group
Source: Scientific reports, 2018, v. 8, no. 1, 2927 How to cite?
Journal: Scientific reports 
Abstract: Manipulating and focusing light deep inside biological tissue and tissue-like complex media has been desired for long yet considered challenging. One feasible strategy is through optical wavefront engineering, where the optical scattering-induced phase distortions are time reversed or pre-compensated so that photons travel along different optical paths interfere constructively at the targeted position within a scattering medium. To define the targeted position, an internal guidestar is needed to guide or provide a feedback for wavefront engineering. It could be injected or embedded probes such as fluorescence or nonlinear microspheres, ultrasonic modulation, as well as absorption perturbation. Here we propose to use a magnetically controlled optical absorbing microsphere as the internal guidestar. Using a digital optical phase conjugation system, we obtained sharp optical focusing within scattering media through time-reversing the scattered light perturbed by the magnetic microsphere. Since the object is magnetically controlled, dynamic optical focusing is allowed with a relatively large field-of-view by scanning the magnetic field externally. Moreover, the magnetic microsphere can be packaged with an organic membrane, using biological or chemical means to serve as a carrier. Therefore, the technique may find particular applications for enhanced targeted drug delivery, and imaging and photoablation of angiogenic vessels in tumours.
EISSN: 2045-2322
DOI: 10.1038/s41598-018-21258-4
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