Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/77617
Title: | Characterization of retinal ganglion cell and optic nerve phenotypes caused by sustained intracranial pressure elevation in mice | Authors: | Shen, G Link, S Kumar, S Nusbaum, DM Tse, DY Fu, Y Wu, SM Frankfort, BJ |
Issue Date: | 2018 | Source: | Scientific reports, 12 2018, v. 8, no. 1, 2856, p. 1-11 | Abstract: | Elevated intracranial pressure (ICP) can result in multiple neurologic sequelae including vision loss. Inducible models of ICP elevation are lacking in model organisms, which limits our understanding of the mechanism by which increased ICP impacts the visual system. We adapted a mouse model for the sustained elevation of ICP and tested the hypothesis that elevated ICP impacts the optic nerve and retinal ganglion cells (RGCs). ICP was elevated and maintained for 2 weeks, and resulted in multiple anatomic changes that are consistent with human disease including papilledema, loss of physiologic cupping, and engorgement of the optic nerve head. Elevated ICP caused a loss of RGC somas in the retina and RGC axons within the optic nerve, as well as a reduction in both RGC electrical function and contrast sensitivity. Elevated ICP also caused increased hypoxia-inducible factor (HIF)-1 alpha expression in the ganglion cell layer. These experiments confirm that sustained ICP elevation can be achieved in mice and causes phenotypes that preferentially impact RGCs and are similar to those seen in human disease. With this model, it is possible to model human diseases of elevated ICP such as Idiopathic Intracranial Hypertension and Spaceflight Associated Neuro-ocular Syndrome. | Publisher: | Nature Publishing Group | Journal: | Scientific reports | EISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-21254-8 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2018 The following publication Shen, G., Link, S., Kumar, S. et al. Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice. Sci Rep 8, 2856 (2018) is available at https://dx.doi.org/10.1038/s41598-018-21254-8 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Shen_Retinal_Ganglion_Cell.pdf | 2.52 MB | Adobe PDF | View/Open |
Page views
118
Last Week
1
1
Last month
Citations as of May 5, 2024
Downloads
53
Citations as of May 5, 2024
SCOPUSTM
Citations
17
Last Week
0
0
Last month
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
14
Last Week
0
0
Last month
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.