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Title: | Metabolic correlates of health-related quality of life among overweight and obese adolescents | Authors: | Lee, CT Lin, CY Strong, C Lin, YF Chou, YY Tsai, MC |
Issue Date: | 2018 | Source: | BMC pediatrics, 2018, v. 18, 25, p. 1-8 | Abstract: | Background: Little is known about the metabolic factors associated with the health-related quality of life (HRQOL) among obese youths. The aim of this study is to assess metabolic correlates of HRQOL in a clinical sample of Taiwanese overweight and obese (OW/OB) adolescents. Methods: OW/OB adolescents (age 11-19 years) were recruited and compared to their normal-weight counterparts in a tertiary hospital. HRQOL was assessed by the Pediatric Quality of Life Inventory (PedsQL). Student t tests and Cohen's d were used to compare the differences in the PedsQL scores between normal-weight and OW/OB participants who were stratified by their cumulative number of cardiometabolic risk factors (CRF). Pearson's correlation and multivariate linear regression analyses were applied to identify predictors of PedsQL. Results: OW/OB adolescents (n=60) reported lower PedsQL scores than those of normal-weight peers. The negative effects were even larger in OW/OB participants with more than one CRF. Body mass index z-scores and serum alanine aminotransferase (ALT) levels were negatively correlated with overall and subscales of PedsQL (r=-0.283 to -0.431). Multivariate linear models showed ALT to be the most salient factor associated with poor obesity-related HRQOL. Conclusion: Taiwanese OW/OB adolescents, particularly those having additional CRF, reported worse HRQOL. Impaired liver functions may predispose OW/OB subjects to even worse HRQOL. | Keywords: | Adolescent Cardiometabolic risk Health-related quality of life Obesity |
Publisher: | BioMed Central | Journal: | BMC pediatrics | EISSN: | 1471-2431 | DOI: | 10.1186/s12887-018-1044-8 | Rights: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The following publication Lee, C. T., Lin, C. Y., Strong, C., Lin, Y. F., Chou, Y. Y., & Tsai, M. C. (2018). Metabolic correlates of health-related quality of life among overweight and obese adolescents. BMC Pediatrics, 18, 25, 1-8 is available at https://dx.doi.org/10.1186/s12887-018-1044-8 |
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