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Title: Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong
Authors: Wang, XL
Wong, CM
Chan, KH
Chan, KP
Cao, PH
Peiris, JSM
Yang, L
Keywords: Hospitalization
Issue Date: 2014
Publisher: Biomed Central Ltd
Source: BMC infectious diseases, 2014, v. 14, no. 1, 32 How to cite?
Journal: BMC Infectious Diseases 
Abstract: Background: Reliable assessment for the severity of the 2009 H1N1 pandemic influenza is critical for evaluation of vaccination strategies for future pandemics. This study aims to estimate the age-specific hospitalization risks of the 2009 pandemic cases during the first wave in Hong Kong, by combining the findings from the serology and disease burden studies.Methods: Excess hospitalization rates associated with the pandemic H1N1 were estimated from Poisson regression models fitted to weekly total numbers of non-accidental hospitalization from 2005 to 2010. Age-specific infection-hospitalization risks were calculated as excess hospitalization rates divided by the attack rates in the corresponding age group, which were estimated from serology studies previously conducted in Hong Kong.Results: Excess hospitalization rate associated with pandemic H1N1 was highest in the 0-4 age group (881.3 per 100,000 population), followed by the 5-14, 60+, 15-29, 50-59, 30-39 and 40-49 age groups. The hospitalization risk of the infected cases (i.e. infection-hospitalization risk) was found highest in the 60+ age group and lowest in the 15-29 age group, with the estimates of 17.5% and 0.7%, respectively.Conclusions: People aged 60 or over had a relatively high infection-hospitalization risk during the first wave of the 2009 H1N1 pandemic, despite of a low attack rate in this age group. The findings support the policy of listing older people as the priority group for pandemic vaccination.
ISSN: 1471-2334
DOI: 10.1186/1471-2334-14-32
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