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http://hdl.handle.net/10397/77217
Title: | Lab-on-a-chip device made by autohesion-bonded polymers | Authors: | Awaja, F Wong, TT Arhatari, B |
Issue Date: | 2018 | Source: | Biomedical microdevices, 2018, v. 20, no. 17 | Abstract: | Polymers have the obvious advantages of flexibility in design and cost effectiveness to fabricate a lab-on-a-chip (LOC) device. Polyether ether ketone (PEEK) in particular is very attractive choice as it adds biocompatibility in addition to the possibility of hematic sealing in a 3D design. Hereby, we extend our previous successful technology of autohesive hermetic bonding of medical implants into lab-on-a-chip devices. We explore a conceptual 3D micro channels design with hermetic potential using PEEK and PS sheets. A hermetic and mechanically strong (through tensile test) 3D multilayer device was obtained using plasma treatment with oxygen and methane as precursors followed by pressing at temperature near of Tg + 20 of the polymer with the lowest Tg (PS). This nanotexturing technique is also used to facilitate thermal and mechanical stability of the microchannels for microfluidic applications. X-ray tomography measurements showed that 3D polymer made chips, at certain plasma and press bonding conditions, have structural integrity and no deformation were detected in channels shape post thermal pressing process. The dimension stability of channels and reservoirs and the rigid interfacial region at PEEK-PS make this chip design attractive and feasible for advanced lab-on-a-chip applications. | Keywords: | Lab-on-a-chip Microfabrication Microfluidics Plasma treatment Sealing |
Publisher: | Springer | Journal: | Biomedical microdevices | EISSN: | 1387-2176 | DOI: | 10.1007/s10544-017-0250-8 | Rights: | © The Author(s) 2017. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The following publication Awaja, F., Wong, Tt. & Arhatari, B. (2018). Lab-on-a-chip device made by autohesion-bonded polymers. Biomedical microdevices, 20, 7 is available at https://doi.org/10.1007/s10544-017-0250-8 |
Appears in Collections: | Journal/Magazine Article |
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