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http://hdl.handle.net/10397/77159
Title: | Assessment of corneal biomechanical properties with inflation test using optical coherence tomography | Authors: | Wang, L Tian, L Huang, Y Huang, Y Zheng, Y |
Issue Date: | Feb-2018 | Source: | Annals of biomedical engineering, Feb. 2018, v. 46, no. 2, p. 247-256 | Abstract: | Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method. Intra-ocular pressure was changed from 10 to 90 mmHg using two different loading rates to observe the pressure-apex displacement relationship and calculate the apparent stiffness of the corneas. Stiffness of the corneal phantoms obtained by the inflation test ranged from 0.2 to 1 MPa, which was highly consistent with the results from the mechanical tensile test (y = 0.70x, p < 0.001). The porcine corneas showed highly viscoelastic behavior with obvious hysteresis in inflation. The apparent stiffness of the porcine corneas was 0.63 ± 0.07 and 1.05 ± 0.08 MPa with loading rates of 3.3 and 33 mmHg/min, respectively. Mapping of corneal surface displacement was also generated for both the phantom and porcine corneas. This study showed that it is feasible to incorporate the high resolution OCT imaging in inflation test to measure the biomechanical properties of the cornea. | Keywords: | Deformation Elasticity Imaging Stiffness Viscoelasticity Young’s modulus |
Publisher: | Springer | Journal: | Annals of biomedical engineering | ISSN: | 0090-6964 | EISSN: | 1573-9686 | DOI: | 10.1007/s10439-017-1973-7 | Rights: | © 2017 Biomedical Engineering Society This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use(https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10439-017-1973-7. |
Appears in Collections: | Journal/Magazine Article |
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Zheng_Assessment_Corneal_Biomechanical.pdf | Pre-Published version | 2.23 MB | Adobe PDF | View/Open |
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