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|Title:||Genetic association study of kCNQ5 polymorphisms with high myopia||Authors:||Liao, X
|Issue Date:||2017||Publisher:||Hindawi Publishing Corporation||Source:||BioMed research international, 2017, 3024156 How to cite?||Journal:||BioMed research international||Abstract:||Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-control study of 1563 unrelated Han Chinese subjects (809 cases of high myopia and 754 emmetropic controls). Five tag single-nucleotide polymorphisms (SNPs) of KCNQ5 were genotyped, and association testing with high myopia was conducted using logistic regression analysis adjusted for sex and age to give P-asym values, and multiple comparisons were corrected by permutation test to give P-emp values. All five noncoding SNPs were associated with high myopia. The SNP rs7744813, previously shown to be associated with refractive error and myopia in two GWAS, showed an odds ratio of 0.75 (95% CI 0.63-0.90; P-emp = 0.0058) for the minor allele. The top SNP rs9342979 showed an odds ratio of 0.75 (95% CI 0.64-0.89; P-emp = 0.0045) for the minor allele. Both SNPs are located within enhancer histone marks and DNase-hypersensitive sites. Our data support the involvement of KCNQ5 gene polymorphisms in the genetic susceptibility to high myopia and further exploration of KCNQ5 as a risk factor for high myopia.||URI:||http://hdl.handle.net/10397/76499||ISSN:||2314-6133||EISSN:||2314-6141||DOI:||10.1155/2017/3024156||Rights:||Copyright © 2017 Xuan Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Xuan Liao, Maurice K. H. Yap, Kim Hung Leung, Patrick Y. P. Kao, Long Qian Liu, and Shea Ping Yip, “Genetic Association Study of KCNQ5 Polymorphisms with High Myopia,” BioMed Research International, vol. 2017, Article ID 3024156, 7 pages, 2017 is available at https://doi.org/10.1155/2017/3024156.
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