Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76188
PIRA download icon_1.1View/Download Full Text
Title: Vitamin D deficiency, oxidative stress and antioxidant status : only weak association seen in the absence of advanced age, obesity or pre-existing disease
Authors: Wang, EW 
Siu, PM 
Pang, MY 
Woo, J
Collins, AR
Benzie, IFF 
Issue Date: 14-Jul-2017
Source: British journal of nutrition, 14 July 2017, v. 118, no. 1, p. 11-16
Abstract: Vitamin D deficiency (plasma 25-hydroxycholecalciferol (25(OH)D) < 50 nmol/l) is highly prevalent, increases risk of non-communicable diseases (NCD) and associates with increased oxidative stress in obese subjects, the elderly and patients suffering from NCD. If confirmed as an independent driver of oxidative stress, nutritional and other public health strategies to improve vitamin D status would be strongly supported. We investigated vitamin D/oxidative stress links without the confounding effects of advanced age, obesity, smoking or pre-existing disease. Plasma 25(OH)D and biomarkers of oxidative stress and antioxidant status (plasma allantoin, oxidised LDL, ferric reducing antioxidant power (FRAP), ascorbic acid, urine 8-oxo-7,8-dihydro-2 '-deoxyguanosine) were measured in fasting samples from 196 consenting, healthy adults aged 18-26 years. Correlation between 25(OH)D and each biomarker as well as biomarker differences across 25(OH)D quartiles and groups (< 25/25-49/>= 50 nmol/l) were investigated. Median 25(OH)D was 40 nmol/l; > 70% of participants were vitamin D deficient. No significant correlations and no biomarker differences across 25(OH)D quartiles or groups were seen except for total antioxidant status. A weak direct association (r 0.252, P < 0.05) was observed between 25(OH)D and FRAP, and those in the lowest 25(OH)D quartile and group had significantly lower FRAP values. Results did not reveal a clear link between vitamin D status and oxidative stress biomarkers in the absence of advanced age, obesity and disease, though some evidence of depleted antioxidant status in those with vitamin D deficiency was seen. Poor antioxidant status may pre-date increased oxidative stress. Study of effects of correction of deficiency on antioxidant status and oxidative stress in vitamin D-deficient but otherwise healthy subjects is needed.
Keywords: Vitamin D
25-Hydroxycholecalciferol
Oxidative stress
Allantoin
8-Oxo-7,8-dihydro-2'-deoxyguanosine
Oxidised LDL
Ferric reducing antioxidant power
Publisher: Cambridge University Press
Journal: British journal of nutrition 
ISSN: 0007-1145
EISSN: 1475-2662
DOI: 10.1017/S000711451700188X
Rights: © The Authors 2017
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
out.pdf207.74 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

106
Last Week
0
Last month
Citations as of Mar 24, 2024

Downloads

36
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

30
Last Week
0
Last month
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

24
Last Week
0
Last month
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.