Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76044
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Title: Chiral differentiation of amino acids through binuclear copper bound tetramers by ion mobility mass spectrometry
Authors: Yu, XY 
Yao, ZP 
Issue Date: 2017
Source: Analytica chimica acta, 2017, v. 981, p. 62-70
Abstract: In this study, travelling wave ion mobility mass spectrometry has been used to investigate chiral differentiation of common chiral amino acids, through separation of binuclear copper bound tetrameric ions formed with chiral selector tryptophan, proline, tyrosine, phenylalanine or histidine. Significant chiral recognition was observed for amino acids with aromatic rings or long and active side chains, with peak-to-peak resolutions up to 1.826. Tryptophan and histidine offered better enantioselectivity, compared to other chiral selectors. The results suggested that the mechanism for chiral recognition in ion mobility mass spectrometry might be significantly different from that in tandem mass spectrometry. Linear calibration curves were also established to allow determination of enantiomeric excess of the analytes by the approach. This study showed that higher assembly of chiral analyte and chiral selector might enable better chiral discrimination and ion mobility mass spectrometry could be a powerful technique for provide qualitative, quantitative and structural information of chiral analysis.
Keywords: Ion mobility mass spectrometry
Chiral recognition
Determination of enantiomeric excess
Binuclear copper bound tetrameric ions
Amino acids
Publisher: Elsevier
Journal: Analytica chimica acta 
ISSN: 0003-2670
EISSN: 1873-4324
DOI: 10.1016/j.aca.2017.05.026
Rights: © 2017 Elsevier B.V. All rights reserved.
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
The following publication Yu, X., & Yao, Z. P. (2017). Chiral differentiation of amino acids through binuclear copper bound tetramers by ion mobility mass spectrometry. Analytica Chimica Acta, 981, 62-70 is available at https://doi.org/10.1016/j.aca.2017.05.026.
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