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http://hdl.handle.net/10397/75870
Title: | Conjugated polymer for voltage-controlled release of molecules | Authors: | Liu, SH Fu, Y Li, GJ Li, L Law, HKW Chen, XF Yan, F |
Issue Date: | 2017 | Source: | Advanced materials, 2017, v. 29, no. 35, 1701733 | Abstract: | Conjugated polymers are attractive in numerous biological applications because they are flexible, biocompatible, cost-effective, solution-processable, and electronic/ionic conductive. One interesting application is for controllable drug release, and this has been realized previously using organic electronic ion pumps. However, organic electronic ion pumps show high operating voltages and limited transportation efficiency. Here, the first report of low-voltage-controlled molecular release with a novel organic device based on a conjugated polymer poly(3-hexylthiophene) is presented. The releasing rate of molecules can be accurately controlled by the duration of the voltage applied on the device. The use of a handy mobile phone to remotely control the releasing process and its application in delivering an anticancer drug to treat cancer cells are also successfully demonstrated. The working mechanism of the device is attributed to the unique switchable permeability of poly(3-hexylthiophene) in aqueous solutions under a bias voltage that can tune the wettability of poly(3-hexylthiophene) via oxidation or reduction processes. The organic devices are expected to find many promising applications for controllable drug delivery in biological systems. | Keywords: | Conjugated polymers Controlled release Organic bioelectronics Organic semiconductors Tunable wettability |
Publisher: | Wiley-VCH | Journal: | Advanced materials | ISSN: | 0935-9648 | EISSN: | 1521-4095 | DOI: | 10.1002/adma.201701733 | Rights: | © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. The following publication Liu, S., Fu, Y., Li, G., Li, L., Law, H. K. W., Chen, X., & Yan, F. (2017). Conjugated Polymer for Voltage‐Controlled Release of Molecules. Advanced Materials, 29(35), 1701733 is available at https://doi.org/10.1002/adma.201701733 |
Appears in Collections: | Journal/Magazine Article |
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