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Title: Differences in risk factors for retinopathy of prematurity development in paired twins: A Chinese population study
Authors: Yau, GSK
Lee, JWY
Tam, VTY
Yip, S 
Cheng, E
Liu, CCL 
Chu, BCY
Yuen, CYF
Issue Date: 2014
Publisher: Hindawi Publishing Corporation
Source: The scientific world journal, 2014, v. 2014, 212183 How to cite?
Journal: The scientific world journal 
Abstract: Purpose. To determine the differences in risk factors for retinopathy of prematurity (ROP) in paired twins. Methods. A retrospective medical record review was performed for all paired twins screened for ROP between 2007 and 2012. Screening was offered to very low birth weight (≤1500 grams) and preterm (≤32 weeks) neonates. Twins 1 and 2 were categorized based on the order of delivery. Maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP. Results. In 34 pairs of Chinese twins, the mean gestational age (GA) was 30.2 ± 2.0 weeks. In Twin 1, smaller GA (OR = 0.44, P=0.02), higher mean oxygen concentration (OR = 1.34, P=0.03), presence of thrombocytopenia (OR = 1429.60, P<0.0001), and intraventricular hemorrhage (OR = 18.67, P=0.03) were significant risk factors for ROP. For Twin 2, a smaller GA (OR = 0.45, P=0.03) was the only risk factor. There were no significant risk factors for ROP in Twin 1 or Twin 2 on multivariate analysis. Conclusion. In Chinese twin pairs, smaller GA was the only common risk factor for ROP while Twin 1 was more susceptible to the postnatal risks for ROP.
ISSN: 2356-6140
EISSN: 1537-744X
DOI: 10.1155/2014/212183
Rights: Copyright © 2014 Gordon S. K. Yau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Yau, G. S., Lee, J. W., Tam, V. T., Yip, S., Cheng, E., Liu, C. C., ... & Yuen, C. Y. (2014). Differences in risk factors for retinopathy of prematurity development in paired twins: a Chinese population study. The Scientific World Journal, 2014, is available at https//
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