Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7571
Title: Nanotherapeutics in angiogenesis : synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos
Authors: Cheng, J
Gu, YJ
Wang, Y
Cheng, SH
Wong, WT 
Keywords: Carbon nanotubes
Drug delivery
Antiangiogenic therapy
Issue Date: Sep-2011
Publisher: Dove Medical Press
Source: International journal of nanomedicine, Sep 2011, v. 2011:6, p. 2007-2021 How to cite?
Journal: International journal of nanomedicine 
Abstract: Background: Carbon nanotubes have shown broad potential in biomedical applications, given their unique mechanical, optical, and chemical properties. In this pilot study, carbon nanotubes have been explored as multimodal drug delivery vectors that facilitate antiangiogenic therapy in zebrafish embryos.
Methods: Three different agents, ie, an antiangiogenic binding site (cyclic arginine-glycin-easpartic acid), an antiangiogenic drug (thalidomide), and a tracking dye (rhodamine), were conjugated onto single-walled carbon nanotubes (SWCNT). The biodistribution, efficacy, and biocompatibility of these triple functionalized SWCNT were tested in mammalian cells and validated in transparent zebrafish embryos.
Results: Accumulation of SWCNT-associated nanoconjugates in blastoderm cells facilitated drug delivery applications. Mammalian cell xenograft assays demonstrated that these antiangiogenic SWCNT nanoconjugates specifically inhibited ectopic angiogenesis in the engrafted zebrafish embryos.
Conclusion: This study highlights the potential of using SWCNT for generating efficient nanotherapeutics.
URI: http://hdl.handle.net/10397/7571
ISSN: 1176-9114
EISSN: 1178-2013
DOI: 10.2147/IJN.S20145
Rights: © 2011 Cheng et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
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