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Title: Image-guided radiation therapy using computed tomography in radiotherapy
Authors: Fung, WWK
Wu, VWC 
Keywords: Image-guided RT
Treatment verification
Inter-fractional uncertainties
Computed tomography
Issue Date: 2011
Source: Journal of radiotherapy in practice, 2011, v. 10, no. 2, p. 121-136 How to cite?
Journal: Journal of radiotherapy in practice 
Abstract: The sharp dose gradients in intensity-modulated radiation therapy increase the treatment sensitivity to various inter- and intra-fractional uncertainties, in which a slight anatomical change may greatly alter the actual dose delivered. Image-guided radiotherapy refers to the use of advanced imaging techniques to precisely track and correct these patient-specific variations in routine treatment. It can also monitor organ changes during a radiotherapy course. Currently, image-guided radiotherapy using computed tomography has gained much popularity in radiotherapy verification as it provides volumetric images with soft-tissue contrast for on-line tracking of tumour. This article reviews four types of computed tomography-based image guidance systems and their working principles. The system characteristics and clinical applications of the helical, megavoltage, computed tomography, and kilovoltage, cone-beam, computed tomography systems are discussed, given that they are currently the most commonly used systems for radiotherapy verification. This article also focuses on the recent techniques of soft-tissue contrast enhancement, digital tomosynthesis, four-dimensional fluoroscopic image guidance, and kilovoltage/megavoltage, in-line cone-beam imaging. These evolving systems are expected to take over the conventional two-dimensional verification system in the near future and provide the basis for implementing adaptive radiotherapy.
ISSN: 1460-3969
DOI: 10.1017/S1460396910000270
Appears in Collections:Journal/Magazine Article

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