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Title: Coexpression pattern analysis of NPM1-associated genes in chronic myelogenous leukemia
Authors: Wang, F 
Chan, LWC 
Tsui, NBY 
Wong, SCC 
Siu, PM 
Yip, SP 
Yung, BYM 
Issue Date: 2015
Source: BioMed research international, 2015, v. 2015, 610595
Abstract: Background. Nucleophosmin 1 (NPM1) plays an important role in ribosomal synthesis and malignancies, but NPM1 mutations occur rarely in the blast-crisis and chronic-phase chronic myelogenous leukemia (CML) patients. The NPM1-associated gene set (GCM-NPM1), in total 116 genes including NPM1, was chosen as the candidate gene set for the coexpression analysis. We wonder if NPM1-associated genes can affect the ribosomal synthesis and translation process in CML. Results. We presented a distribution-based approach for gene pair classification by identifying a disease-specific cutoff point that classified the coexpressed gene pairs into strong and weak coexpression structures. The differences in the coexpression patterns between the normal and the CML groups were reflected from the overall structure by performing two-sample Kolmogorov-Smirnov test. Our developed method effectively identified the coexpression pattern differences from the overall structure: P value=1.71×10-22<0.05 for the maximum deviation D=0.109. Moreover, we found that genes involved in the ribosomal synthesis and translation process tended to be coexpressed in the CML group. Conclusion. Our developed method can identify the coexpression difference between two different groups. Dysregulation of ribosomal synthesis and translation process may be related to the CML disease. Our significant findings may provide useful information for the novel CML mechanism exploration and cancer treatment.
Publisher: Hindawi Publishing Corporation
Journal: BioMed research international 
ISSN: 2314-6133
EISSN: 2314-6141
DOI: 10.1155/2015/610595
Rights: Copyright © 2015 Fengfeng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Wang, F., Chan, L. W., Tsui, N. B., Wong, S. C., Siu, P. M., Yip, S. P., & Yung, B. Y. (2015). Coexpression pattern analysis of NPM1-associated genes in chronic myelogenous leukemia. BioMed research international, 2015, is available at https//
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