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|Title:||Cardiovascular protective effects of salvianic acid a on db/db mice with elevated homocysteine level||Authors:||Gao, L
|Issue Date:||2017||Publisher:||Hindawi Limited||Source:||Oxidative medicine and cellular longevity, 2017, v. 2017, 9506925 How to cite?||Journal:||Oxidative medicine and cellular longevity||Abstract:||The onsets of left ventricular hypertrophy (LVH) and endothelial dysfunction (ED) in diabetics, especially in those with elevated homocysteine (Hcy), precede the development of cardiovascular (CV) events. Salvianic acid A (SAA) is a renowned Traditional Chinese Medicine (TCM) that has been applied in the treatment of cardiovascular disease for many decades. In this study, we aimed (1) to investigate the CV protective effects of SAA on ameliorating LVH and ED in db/db mice with elevated blood Hcy level and (2) to decipher whether the observed CV protective effects of SAA are associated with Hcy metabolism by modulating the methylation potential and redox status in the liver of the db/db mice with elevated blood Hcy level. Our results found that the administration of SAA could significantly slow down the build-up of left ventricular mass and ameliorate ED. Immunological assay analysis on the mouse liver tissue also indicated that SAA treatment on db/db mice with elevated Hcy was associated with reduced methylation potential but improved redox status. In conclusion, we revealed that SAA has the potential to protect against the hyperglycemia- and hyperhomocysteinemia-induced oxidative stress on diabetic mice via modulation in Hcy metabolism.||URI:||http://hdl.handle.net/10397/74762||ISSN:||1942-0900||EISSN:||1942-0994||DOI:||10.1155/2017/9506925||Rights:||Copyright © 2017 Lei Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Lei Gao, Parco M. Siu, Shun-wan Chan, and Christopher W. K. Lai, “Cardiovascular Protective Effects of Salvianic Acid A on db/db Mice with Elevated Homocysteine Level,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 9506925, 10 pages, 2017 is available at https://doi.org/10.1155/2017/9506925.
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