Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/74703
Title: Influence of hard segments on the thermal, phase-separated morphology, mechanical, and biological properties of polycarbonate urethanes
Authors: Zhu, R
Wang, X
Yang, J
Wang, Y
Zhang, Z
Hou, Y
Lin, F
Li, Y 
Issue Date: 2017
Source: Applied sciences, Mar. 2017, v. 7, no. 3, 306, p. 1-15
Abstract: In this study, we have fabricated a series of polycarbonate polyurethanes using a two-step bulk reaction by the melting pre-polymer solution-casting method in order to synthesize biomedical polyurethane elastomers with good mechanical behavior and biostability. The polyurethanes were prepared using dibutyltin dilaurate as the catalyst, poly(1,6-hexanediol)carbonate microdiols (PCDL) as the soft segment, and the chain extender 1,4-butanediol (BDO) and aliphatic 1,6-hexamethylene diisocyanate (HDI) as the hard segments. The chemical structures and physical properties of the obtained films were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, gel permeation chromatography (GPC), differential scanning calorimeter (DSC), and mechanical property tests. The surface properties and degrees of microphase separation were further analyzed by water droplet contact angle measurements (CA) and atomic force microscopy (AFM). The materials exhibited a moderate toxic effect on the tetrazolium (MTT) assay and good hemocompatibility through hemolytic tests, indicating a good biocompatibility of the fabricated membranes. The materials could be considered as potential and beneficial suitable materials for tissue engineering, especially in the fields of artificial blood-contacting implants or other biomedical applications.
Keywords: Biocompatibility
Hard segment
Mechanical behavior
Polyurethanes
Publisher: MDPI AG
Journal: Applied sciences 
ISSN: 2076-3417
DOI: 10.3390/APP7030306
Rights: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The following publication Zhu, R., Wang, X., Yang, J., Wang, Y., Zhang, Z., Hou, Y., … Li, Y. (2017). Influence of hard segments on the thermal, phase-separated morphology, mechanical, and biological properties of polycarbonate urethanes. Applied Sciences, 7(3), (Suppl. ), 306, - is available athttps://dx.doi.org/10.3390/APP7030306
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