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http://hdl.handle.net/10397/72216
Title: | Gadolinium and platinum in tandem : real-time multi-modal monitoring of drug delivery by MRI and fluorescence imaging | Authors: | Li, H Harriss, BI Phinikaridou, A Lacerda, S Ramniceanu, G Doan, BT Ho, KL Chan, CF Lo, WS Botnar, RM Lan, R Richard, C Law, GL Long, NJ Wong, KL |
Issue Date: | 2017 | Source: | Nanotheranostics, 2017, v. 1, no. 2, p. 186-195 | Abstract: | A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM-1s-1 at 3T, 25 oC) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation. | Keywords: | Prodrug Multi-modal MRI Drug delivery Fluorescence imaging Cisplatin |
Publisher: | Ivyspring International Publisher | Journal: | Nanotheranostics | ISSN: | 2206-7418 | DOI: | 10.7150/ntno.18619 | Rights: | © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. The following publication Li, H., Harriss, B. I., Phinikaridou, A., Lacerda, S., Ramniceanu, G., Doan, B. T., ... & Lan, R. (2017). Gadolinium and platinum in tandem: real-time multi-modal monitoring of drug delivery by MRI and fluorescence imaging. Nanotheranostics, 1(2), 186-195 is available at https://doi.org/10.7150/ntno.18619 |
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