Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7060
Title: Effects of Panax ginseng-containing herbal plasters on compressed intervertebral discs in an in vivo rat tail model
Authors: Chow, DHK
Lai, A
Tang, FH
Leung, CP
Issue Date: 18-Feb-2013
Publisher: BioMed Central Ltd.
Source: Chinese medicine, 18 Feb. 2013, v. 8, 4, p. 1-8 How to cite?
Journal: Chinese medicine 
Abstract: Background: Tienchi (Panax notoginseng) has been used in conservative treatments for back pain as a major ingredient of many herbal medicines. This study aims to investigate the effects of a herbal medicine containing tienchi on compressed intervertebral discs in rats.
Methods: Using an in vivo rat tail model, intervertebral disc compression was simulated in the caudal 8–9 discs of 25 rats by continuous static compression (11 N) for 2 weeks. An herbal medicine plaster (in which the major ingredient was tienchi) was externally applied to the compressed disc (n=9) for three weeks, and held in place by an adhesive bandage, in animals in the Chinese Medicine (CM) group. The effect of the bandage was evaluated in a separate placebo group (n=9), while no intervention with unrestricted motion was provided to rats in an additional control group (n=7). Disc structural properties were quantified by in vivo disc height measurement and in vitro morphological analysis.
Results: Disc height decreased after the application of compression (P < 0.001). The disc height decreased continuously in the control (P = 0.006) and placebo (P = 0.003) groups, but was maintained in the CM group (P = 0.494). No obvious differences in disc morphology were observed among the three groups (P = 0.896).
Conclusion: The tienchi-containing herbal plaster had no significant effect on the morphology of compressed discs, but maintained disc height in rats.
URI: http://hdl.handle.net/10397/7060
ISSN: 1749-8546
DOI: 10.1186/1749-8546-8-4
Rights: © 2013 Chow et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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