Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/7060
Title: | Effects of Panax ginseng-containing herbal plasters on compressed intervertebral discs in an in vivo rat tail model | Authors: | Chow, DHK Lai, A Tang, FH Leung, CP |
Issue Date: | 18-Feb-2013 | Source: | Chinese medicine, 18 Feb. 2013, v. 8, 4, p. 1-8 | Abstract: | Background: Tienchi (Panax notoginseng) has been used in conservative treatments for back pain as a major ingredient of many herbal medicines. This study aims to investigate the effects of a herbal medicine containing tienchi on compressed intervertebral discs in rats. Methods: Using an in vivo rat tail model, intervertebral disc compression was simulated in the caudal 8–9 discs of 25 rats by continuous static compression (11 N) for 2 weeks. An herbal medicine plaster (in which the major ingredient was tienchi) was externally applied to the compressed disc (n=9) for three weeks, and held in place by an adhesive bandage, in animals in the Chinese Medicine (CM) group. The effect of the bandage was evaluated in a separate placebo group (n=9), while no intervention with unrestricted motion was provided to rats in an additional control group (n=7). Disc structural properties were quantified by in vivo disc height measurement and in vitro morphological analysis. Results: Disc height decreased after the application of compression (P < 0.001). The disc height decreased continuously in the control (P = 0.006) and placebo (P = 0.003) groups, but was maintained in the CM group (P = 0.494). No obvious differences in disc morphology were observed among the three groups (P = 0.896). Conclusion: The tienchi-containing herbal plaster had no significant effect on the morphology of compressed discs, but maintained disc height in rats. |
Publisher: | BioMed Central Ltd. | Journal: | Chinese medicine | ISSN: | 1749-8546 | DOI: | 10.1186/1749-8546-8-4 | Rights: | © 2013 Chow et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Chow_Panax_Ginseng-containing_Intervertebral.pdf | 1.5 MB | Adobe PDF | View/Open |
Page views
133
Last Week
1
1
Last month
Citations as of Apr 21, 2024
Downloads
132
Citations as of Apr 21, 2024
SCOPUSTM
Citations
4
Last Week
0
0
Last month
0
0
Citations as of Apr 5, 2024
WEB OF SCIENCETM
Citations
2
Last Week
0
0
Last month
0
0
Citations as of Apr 25, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.