Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7028
Title: Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi) : results of a controlled human intervention trial
Authors: Chu, TTW
Benzie, IFF 
Lam, CWK
Fok, BSP
Lee, KKC
Tomlinson, B
Keywords: Antioxidants
Lipids
Ganoderma lucidum (Lingzhi)
Insulin
Issue Date: Apr-2012
Publisher: Cambridge University Press published on behalf of the Nutrition Society
Source: British journal of nutrition, Apr. 2012, v. 107, no. 7, p. 1017-1027 How to cite?
Journal: British journal of nutrition 
Abstract: Previous studies have suggested that Lingzhi (Ganoderma lucidum) has antioxidant effects and possibly beneficial effects on blood pressure, plasma lipids and glucose, but these have not been confirmed in subjects with mild hypertension or hyperlipidaemia. The objective of the present study was to assess the cardiovascular, metabolic, antioxidant and immunomodulatory responses to therapy with Lingzhi in patients with borderline elevations of blood pressure and/or cholesterol in a controlled cross-over trial. A total of twenty-six patients received 1·44 g Lingzhi daily or matching placebo for 12 weeks in a randomised, double-blind, cross-over study with placebo-controlled run-in and cross-over periods. Body weight, blood pressure, metabolic parameters, urine catecholamines and cortisol, antioxidant status and lymphocyte subsets were measured after each period. Lingzhi was well tolerated and data from twenty-three evaluable subjects showed no changes in BMI or blood pressure when treated with Lingzhi or placebo. Plasma insulin and homeostasis model assessment-insulin resistance were lower after treatment with Lingzhi than after placebo. TAG decreased and HDL-cholesterol increased with Lingzhi but not with placebo in the first treatment period, but significant carry-over effects prevented complete analysis of these parameters. Urine catecholamines and cortisol, plasma antioxidant status and blood lymphocyte subsets showed no significant differences across treatments. Results indicate that Lingzhi might have mild antidiabetic effects and potentially improve the dyslipidaemia of diabetes, as shown previously in some animal studies. Further studies are desirable in patients with hyperglycaemia.
URI: http://hdl.handle.net/10397/7028
ISSN: 0007-1145 (print)
1475-2662 (EISSN)
DOI: 10.1017/S0007114511003795
Rights: © The Authors 2011
The following article "Tanya T. W. Chu, Iris F. F. Benzie, Christopher W. K. Lam, Benny S. P. Fok, Kenneth K. C. Lee and Brian Tomlinson (2012). Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. British Journal of Nutrition, 107, pp 1017-1027. doi:10.1017/S0007114511003795." is available at http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8525284
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