Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/66055
Title: Neural bases of congenital amusia in tonal language speakers
Authors: Zhang, C 
Peng, G
Shao, J
Wang, WSY
Keywords: Cantonese
Congenital amusia
FMRI
Lexical tone
Music
Neural bases
Issue Date: Mar-2017
Publisher: Pergamon Press
Source: Neuropsychologia, 2017, v. 97, p. 18-28 How to cite?
Journal: Neuropsychologia 
Abstract: Congenital amusia is a lifelong neurodevelopmental disorder of fine-grained pitch processing. In this fMRI study, we examined the neural bases of congenial amusia in speakers of a tonal language – Cantonese. Previous studies on non-tonal language speakers suggest that the neural deficits of congenital amusia lie in the music-selective neural circuitry in the right inferior frontal gyrus (IFG). However, it is unclear whether this finding can generalize to congenital amusics in tonal languages. Tonal language experience has been reported to shape the neural processing of pitch, which raises the question of how tonal language experience affects the neural bases of congenital amusia. To investigate this question, we examined the neural circuitries sub-serving the processing of relative pitch interval in pitch-matched Cantonese level tone and musical stimuli in 11 Cantonese-speaking amusics and 11 musically intact controls. Cantonese-speaking amusics exhibited abnormal brain activities in a widely distributed neural network during the processing of lexical tone and musical stimuli. Whereas the controls exhibited significant activation in the right superior temporal gyrus (STG) in the lexical tone condition and in the cerebellum regardless of the lexical tone and music conditions, no activation was found in the amusics in those regions, which likely reflects a dysfunctional neural mechanism of relative pitch processing in the amusics. Furthermore, the amusics showed abnormally strong activation of the right middle frontal gyrus and precuneus when the pitch stimuli were repeated, which presumably reflect deficits of attending to repeated pitch stimuli or encoding them into working memory. No significant group difference was found in the right IFG in either the whole-brain analysis or region-of-interest analysis. These findings imply that the neural deficits in tonal language speakers might differ from those in non-tonal language speakers, and overlap partly with the neural circuitries of lexical tone processing (e.g. right STG).
URI: http://hdl.handle.net/10397/66055
ISSN: 0028-3932
EISSN: 1873-3514
DOI: 10.1016/j.neuropsychologia.2017.01.033
Rights: © 2017 Elsevier Ltd. All rights reserved.
NOTICE: this is the author’s version of a work that was accepted for publication in Neuropsychologia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version Zhang, C., Peng, G., Shao, J., & Wang, W. S. Y. (2017). Neural bases of congenital amusia in tonal language speakers. Neuropsychologia, 97, 18-28 is available at https://doi.org/10.1016/j.neuropsychologia.2017.01.033
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