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Title: Potential involvement of Type I interferon signaling in immunotherapy in seasonal allergic rhinitis
Authors: Mattson, L
Lentini, A
Gawel, DR
Badam, TVS
Benson, M
Ledin, T
Nestor, CE
Gustafsson, M
Serra-Musach, J
Bjorkander, J
Zou, X 
Zhang, H
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Source: Journal of immunology research, 2016, v. 2016, 5153184, p.1-6 How to cite?
Journal: Journal of immunology research 
Abstract: Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.
ISSN: 2314-8861
EISSN: 2314-7156
DOI: 10.1155/2016/5153184
Rights: Copyright ⓒ 2016 Lina Mattson et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Creative Commons Attribution License is located at
The following publication Mattson, L., Lentini, A., Gawel, D. R., Badam, T. V., Benson, M., Ledin, T., ... & Zou, X. (2016). Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis. Journal of immunology research, 2016, 5153184 is available at
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