Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/6603
Title: A Chan dietary intervention enhances executive functions and anterior cingulate activity in autism spectrum disorders : a randomized controlled trial
Authors: Chan, AS
Sze, SL
Han, YMY
Cheung, MC
Keywords: Electromagnetic tomography
Response-inhibition
Prefrontal cortex
Central coherence
Vegetarian diets
Young-children
Deficits
Adults
Brain
Individuals
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Source: Evidence-based complementary and alternative medicine, 2012, v. 2012, 262136, p. 1-11 How to cite?
Journal: Evidence-based complementary and alternative medicine 
Abstract: Executive dysfunctions have been found to be related to repetitive/disinhibited behaviors and social deficits in autism spectrum disorders (ASDs). This study aims to investigate the potential effect of a Shaolin-medicine-based dietary modification on improving executive functions and behavioral symptoms of ASD and exploring the possible underlying neurophysiological mechanisms. Twenty-four children with ASD were randomly assigned into the experimental (receiving dietary modification for one month) and the control (no modification) groups. Each child was assessed on his/her executive functions, behavioral problems based on parental ratings, and event-related electroencephalography (EEG) activity during a response-monitoring task before and after the one month. The experimental group demonstrated significantly improved mental flexibility and inhibitory control after the diet modification, which continued to have a large effect size within the low-functioning subgroup. Such improvements coincided with positive evaluations by their parents on social communication abilities and flexible inhibitory control of daily behaviors and significantly enhanced event-related EEG activity at the rostral and subgenual anterior cingulate cortex. In contrast, the control group did not show any significant improvements. These positive outcomes of a one-month dietary modification on children with ASD have implicated its potential clinical applicability for patients with executive function deficits.
URI: http://hdl.handle.net/10397/6603
ISSN: 1741-427X
EISSN: 1741-4288
DOI: 10.1155/2012/262136
Rights: Copyright © 2012 Agnes S. Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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