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http://hdl.handle.net/10397/65718
Title: | A graphene quantum dot@Fe3O4@SiO2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells | Authors: | Su, X Chan, C Shi, J Tsang, MK Pan, Y Cheng, C Oudeng, G Yang, M |
Issue Date: | 15-Jun-2017 | Source: | Biosensors and bioelectronics, 15 June 2017, v. 92, p. 489-495 | Abstract: | A novel graphene quantum dot (GQD)@Fe3O4@SiO2 based nanoprobe was reported for targeted drug delivery, sensing, dual-modal imaging and therapy. Carboxyl-terminated GQD (C-GQD) was firstly conjugated with Fe3O4@SiO2 and then functionalized with cancer targeting molecule folic acid (FA). DOX drug molecules were then loaded on GQD surface of Fe3O4@SiO2@GQD-FA nanoprobe via pi-pi stacking, which resulted in Fe3O4@SiO2@GQD-FA/DOX conjugates based on a FRET mechanism with GQD as donor molecules and DOX as acceptor molecules. Meanwhile, we successfully performed in vitro MRI and fluorescence imaging of living Hela cells and monitored intracellular drug release process using this Fe3O4@SiO2@GQD-FA/DOX nanoprobe. Cell viability study demonstrated the low cytotoxicity of Fe3O4@SiO2@GQD-FA nanocarrier and the enhanced therapeutic efficacy of Fe3O4@SiO2@GQD-FA/DOX nanoprobe for cancer cells. This luminomagnetic nanoprobe will be a potential platform for cancer accurate diagnosis and therapy. | Keywords: | Cell imaging Drug delivery sensing Fluorescence resonance energy transfer (FRET) Graphene quantum dots (GQDs) Magnetic resonance imaging (MRI) |
Publisher: | Elsevier | Journal: | Biosensors and bioelectronics | ISSN: | 0956-5663 | EISSN: | 1873-4235 | DOI: | 10.1016/j.bios.2016.10.076 | Rights: | © 2016 Elsevier B.V. All rights reserved. © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ The following publication Su, X., Chan, C., Shi, J., Tsang, M. K., Pan, Y., Cheng, C., ... & Yang, M. (2017). A graphene quantum dot@ Fe3O4@ SiO2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells. Biosensors and Bioelectronics, 92, 489-495 is available at https://doi.org/10.1016/j.bios.2016.10.076 |
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