Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/65714
Title: Shugan Xiaozhi Decoction attenuates nonalcoholic Steatohepatitis by enhancing PPARα and L-FABP expressions in high-fat-fed rats
Authors: Xing, YF
Zhang, Z
Fu, WJ
Zhou, DQ
Yuen, ACY 
Mok, DKW 
Chan, CO 
Tong, GD
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Source: Evidence-based complementary and alternative medicine, 2016, v. 2016, 7870189 How to cite?
Journal: Evidence-based complementary and alternative medicine 
Abstract: This study aimed to investigate the effects of Shugan Xiaozhi decoction (SX) on nonalcoholic steatohepatitis (NASH) induced by high-fat diet in rats. The rats were randomly divided into 6 groups, namely, control, model, fenofibrate, and three different dosage of SX (10, 20, and 40 g/kg/day, p.o.). After establishing the NASH model, at 8 weeks of the experiment, treatments were administrated intragastrically to the fenofibrate and SX groups. All rats were killed after 4 weeks of treatment. Compared with the model group, alanine aminotransferase (ALT), aspartate aminotransferase (AST), free fatty acid (FFA), total cholesterol (TC), triacylglycerol (TG), and low-density lipoprotein cholesterol (LDL) serum in the serum were significantly reduced in all SX treatment groups in a dose-dependent manner. Evidence showed that SX could protect the liver by upregulating the gene and protein expressions of peroxisome proliferator-activated receptor alpha (PPARα) and liver fatty acid binding protein (L-FABP) in a dose-dependent manner. Chemical constituents of SX were further analyzed by ultraperformance liquid chromatography coupled with electrospray ionization mass spectrometry (UPLC-ESI-MS) and 30 chemicals in the ethanolic extract were tentatively identified. To conclude, our results clearly indicated that SX could protect liver functions and relieve hepatic steatosis and inflammation.
URI: http://hdl.handle.net/10397/65714
ISSN: 1741-427X
EISSN: 1741-4288
DOI: 10.1155/2016/7870189
Rights: Copyright © 2016 Yu-feng Xing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Xing, Y. F., Zhang, Z., Fu, W. J., Zhou, D. Q., Yuen, A. C. Y., Mok, D. K. W., ... & Tong, G. D. (2016). Shugan Xiaozhi Decoction Attenuates Nonalcoholic Steatohepatitis by Enhancing PPAR and L-FABP Expressions in High-Fat-Fed Rats. Evidence-Based Complementary and Alternative Medicine, 2016, is available at https//doi.org/10.1155/2016/7870189
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