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Title: | Meta-analysis of the effects of neuropsychological interventions on cognitive function in non-central nervous system cancer survivors | Authors: | Zeng, Y Cheng, ASK Chan, CCH |
Issue Date: | Dec-2016 | Source: | Integrative cancer therapies, Dec. 2016, v. 15, no. 4, p. 424-434 | Abstract: | Background: Cognitive impairment is a common complaint among cancer survivors, significantly impacting working memory, attention, executive function, and information processing speed. This meta-analysis aims to evaluate the effect of neuropsychological interventions on the cognitive function of non-central nervous system (non-CNS) cancer survivors. Methods: Three databases (PubMed, PsycInfo, and CAJ Full-text Database) were searched from January 2010 to September 2015. Controlled clinical trials of neuropsychological interventions for the treatment of cognitive impairment in cancer survivors were considered for inclusion. Results: A total of 10 eligible trials were included in this meta-analysis. Three trials assessed the effects of cognitive rehabilitation (CR) interventions, and the weighted mean difference (WMD) for the overall intervention effect was -0.19 (95% confidence interval [CI] = -2.98 to 2.61). Two trials examined the effects of cognitive training (CT) interventions on the cognitive function of cancer survivors; the standardized mean difference (SMD) for the overall effect was 0.52 (95% CI = 0.06 to 0.98). The overall effect of CR interventions on neuropsychological status at postintervention was 5.66 (95% CI = 2.97 to 8.35). The SMD of CR and CT intervention for objective function by verbal learning tests was 0.50 (95% CI = 0.19 to 0.81) at postintervention, and 0.58 (95% CI = 0.19-0.98) at follow-up assessment within 6 months. Conclusion: Findings from this meta-analysis indicate that neuropsychological interventions can improve cognitive function in non-CNS cancer survivors, and support the need for future research. However, the conclusion from this meta-analysis was based on trials with small sample sizes. Future research should be conducted using a larger sample size. Relevant clinical implications were discussed accordingly. |
Keywords: | Cancer survivors Cognitive impairment Meta-analysis Neuropsychological interventions |
Publisher: | SAGE Publications | Journal: | Integrative cancer therapies | ISSN: | 1534-7354 | EISSN: | 1552-695X | DOI: | 10.1177/1534735416638737 | Rights: | © The Author(s) 2016 Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). The following publication Zeng, Y., Cheng, A. S., & Chan, C. C. (2016). Meta-analysis of the effects of neuropsychological interventions on cognitive function in non–central nervous system cancer survivors. Integrative cancer therapies, 15(4), 424-434 is available at https://doi.org/10.1177/1534735416638737 |
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