Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/64001
Title: High cholesterol level upregulate the expression of caveolin-1
Other Titles: 高胆固醇上调Caveolin-1的表达
Authors: Ran, YW
Du, JR
Bao, B
Zhang, R
Qian, ZM
Keywords: Caveolea
Caveolin 1
Hypercholesterolemia
Immunohistochemistry
Issue Date: 2004
Publisher: 中國學術期刊 (光盤版) 電子雜誌社
Source: 生物医学工程学杂志 (Journal of biomedical engineering), 2004, v. 21, no. 2, p. 276-279 How to cite?
Journal: 生物医学工程学杂志 (Journal of biomedical engineering) 
Abstract: 为了研究高胆固醇血症对血管内皮细胞膜上 Caveolin- 1表达的影响。用免疫组织化学的方法检测了高胆固醇血清刺激的培养人脐静脉内皮细胞株 ECV- 30 4细胞以及高脂血症大鼠动脉内皮上 Caveolin- 1表达量的动态变化。发现高胆固醇可上调体内外内皮细胞膜上 Caveolin- 1的表达。在高血脂模型初期 ,Caveolin- 1的表达量与高血脂水平的维持时程成正相关 ;在高胆固醇血症模型后期 ,血管内皮细胞膜上 Caveolin- 1的表达略有下降
To study the influence of hypercholesterolemia with caveolin 1 on the plasmalemma of vascular endothelium,we used the methods of immunohistochemistry to detect the dynamic changes of caveolin 1 in cultured ECV 304 cells which were stimulated high cholesterol serum and the arterial endothelium of hypercholesterolemia rats. It is resulted that high cholesteorol level can upregulate the expression of caveolin 1 both in vitro and in vivo. In the initial stage of hypercholesterolemia model,the expression of caveolin 1 increased as the time of high cholesterol level added,but in the later period it was decreased slightly.
URI: http://hdl.handle.net/10397/64001
ISSN: 1001-5515
Rights: © 2004 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。
© 2004 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research purposes.
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