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Title: Inhibitory effect of Herba Epimedii extract on bone turn-over of ovariectomized rats
Other Titles: 淫羊藿提取物对去卵巢大鼠骨转换率增强的抑制作用
Authors: Xie, F
Zhang, Y
Wu, CF
Yao, XS
Wong, MS 
Keywords: Herba Epimedii
Ovariectomy (OVX)
Issue Date: 2005
Publisher: 中草药杂志编辑部
Source: 中草药 (Chinese traditional and herbal drugs), 2005, v. 36, no. 11, p. 1667-1670 How to cite?
Journal: 中草药 (Chinese traditional and herbal drugs) 
Abstract: Objective To investigate the effect of Herba Epimedii extract on bone turn-over in ovariectomized rats.
Methods Three-month old female SD rats were ovariectomized and Sham-operated respectively. One month after ovariectomy (OVX), the rats were given Herba Epimedii extract (110 mg/ kg) and 17β-estrogen (2 mg/kg) by ig for three months continuously. Serum contents of Ca (s-Ca), P (s-P), and ALP as well as urine contents of Ca (u-Ca), P (u-P), and creatinine (Cr) were detected. Urine DPD/Cr was analyzed by ELISA kit. The proximal tibia was processed undecalcified sections of 5 μm for histomorphometric analysis.
Results There was no change among all groups in the levels of s-Ca s-P, and u-P. Serum ALP activity significantly increased in OVX rats with metratrophia compared with Sham group, as well as u-Ca and DPD/Cr. OVX group had lower trabecular bone mass with decreased area percentage of trabecular bone mass and increased suturae of trabecular bone mass. Both Herba Epimedii extract and 17β-estrogen treatment could make serum ALP activity inhibit, u-Ca and DPD/Cr reduce, trabecular bone mass increase, and suturae of trabecular bone mass constrict in tibia widen. Hysterauxesis was found in 17β-estrogen group, while no change was observed in Herba Epimedii extract group compared with model group.
Conclusion Herba Epimedii extract could inhibit the high rate of bone turn-over induced by OVX in rats, without substantial effects on the uterus.
ISSN: 0253-2670
Rights: © 2005 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。
© 2005 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research purposes.
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