Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/63782
Title: Inhibitory effect of Herba Epimedii extract on bone turn-over of ovariectomized rats
Other Titles: 淫羊藿提取物对去卵巢大鼠骨转换率增强的抑制作用
Authors: Xie, F
Zhang, Y
Wu, CF
Yao, XS
Wong, MS 
Keywords: Herba Epimedii
Osteoporosis
Ovariectomy (OVX)
Issue Date: 2005
Publisher: 中草药杂志编辑部
Source: 中草药 (Chinese traditional and herbal drugs), 2005, v. 36, no. 11, p. 1667-1670 How to cite?
Journal: 中草药 (Chinese traditional and herbal drugs) 
Abstract: Objective To investigate the effect of Herba Epimedii extract on bone turn-over in ovariectomized rats.
Methods Three-month old female SD rats were ovariectomized and Sham-operated respectively. One month after ovariectomy (OVX), the rats were given Herba Epimedii extract (110 mg/ kg) and 17β-estrogen (2 mg/kg) by ig for three months continuously. Serum contents of Ca (s-Ca), P (s-P), and ALP as well as urine contents of Ca (u-Ca), P (u-P), and creatinine (Cr) were detected. Urine DPD/Cr was analyzed by ELISA kit. The proximal tibia was processed undecalcified sections of 5 μm for histomorphometric analysis.
Results There was no change among all groups in the levels of s-Ca s-P, and u-P. Serum ALP activity significantly increased in OVX rats with metratrophia compared with Sham group, as well as u-Ca and DPD/Cr. OVX group had lower trabecular bone mass with decreased area percentage of trabecular bone mass and increased suturae of trabecular bone mass. Both Herba Epimedii extract and 17β-estrogen treatment could make serum ALP activity inhibit, u-Ca and DPD/Cr reduce, trabecular bone mass increase, and suturae of trabecular bone mass constrict in tibia widen. Hysterauxesis was found in 17β-estrogen group, while no change was observed in Herba Epimedii extract group compared with model group.
Conclusion Herba Epimedii extract could inhibit the high rate of bone turn-over induced by OVX in rats, without substantial effects on the uterus.
URI: http://hdl.handle.net/10397/63782
ISSN: 0253-2670
Rights: © 2005 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。
© 2005 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research purposes.
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
r28295.pdf140.46 kBAdobe PDFView/Open
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page view(s)

19
Last Week
2
Last month
Checked on Sep 17, 2017

Download(s)

10
Checked on Sep 17, 2017

Google ScholarTM

Check



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.