Grosmomoside I, a new cucurbitane triterpenoid glycoside from fruits of Momordica grosvenori

Abstract

Objective: To carry out a systematic study on the chemical constituents in the fruits of Momordica grosvenori. Methods: To isolate pure compounds by using repeated column chromatography, while the structure of a new compound was determined by detailed spectral analysis. Results: Four cucurbitane triterpenoid glycosides, mogroside Ⅱ_E(Ⅰ), mogroside Ⅲ(Ⅱ), grosmomoside Ⅰ (Ⅲ), and mogroside Ⅴ (Ⅳ) were isolated from the 50% ethanolic extract of the fruits of M. grosvenori. Conclusion: Grosmomoside Ⅰ is a new compound identified as mogrol-3-O-β-D-glucopyranoside-24-O-{[β-D-glucopyranosyl(2-1)]-[β-D-glucopyranosyl (6-1)]-β-D-galactopyranoside} and the other three compounds are known compounds. 目的: 研究罗汉果中的化学成分。 方法: 用各种色谱法分离和精制纯品化合物,通过各种谱学方法鉴定其结构。 结果: 从罗汉果乙醇提取物中得到4个葫芦烷型三萜皂苷,分别为: 罗汉果皂苷E(mogroside ⅡE,Ⅰ)、罗汉果皂苷(mogroside Ⅲ,Ⅱ)、光果木鳖皂苷(grosmomoside Ⅰ, Ⅲ)和罗汉果皂苷(mogroside Ⅴ,Ⅳ)。 结论: 光果木鳖皂苷为一新化合物,鉴定其结构为罗汉果醇-3-O-β-D-吡喃葡萄糖苷-24-O-{[β-D-吡喃葡萄糖基(2-1)]- [β-D-吡喃葡萄糖基(6-1)]-β-D-吡喃半乳糖苷{mogrol-3-O-β-D-glucopyranoside-24-O-[β-D-glucopyranosyl(2-1)]- [β-D-glucopyranosyl(6-1)]-β-D-galactopyranoside},其他3个化合物为已知化合物。