Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62164
Title: Graphene oxide-enhanced sol-gel transition sensitivity and drug release performance of an amphiphilic copolymer-based nanocomposite
Authors: Hu, H
Wang, X
Lee, KI
Ma, K
Hu, H 
Xin, JH 
Issue Date: 2016
Publisher: Nature Publishing Group
Source: Scientific reports, 2016, v. 6 , 31815 How to cite?
Journal: Scientific reports 
Abstract: We report the fabrication of a highly sensitive amphiphilic copolymer-based nanocomposite incorporating with graphene oxide (GO), which exhibited a low-intensity UV light-triggered sol-gel transition. Non-cytotoxicity was observed for the composite gels after the GO incorporation. Of particular interest were the microchannels that were formed spontaneously within the GO-incorporated UV-gel, which expedited sustained drug release. Therefore, the present highly UV-sensitive, non-cytotoxic amphiphilic copolymer-based composites is expected to provide enhanced photothermal therapy and chemotherapy by means of GO's unique photothermal properties, as well as through efficient passive targeting resulting from the sol-gel transition characteristic of the copolymer-based system with improved sensitivity, which thus promises the enhanced treatment of patients with cancer and other diseases.
URI: http://hdl.handle.net/10397/62164
EISSN: 2045-2322
DOI: 10.1038/srep31815
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