Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62162
Title: Metformin improved health-related quality of life in ethnic Chinese women with polycystic ovary syndrome
Authors: Ou, HT
Chen, PC
Wu, MH
Lin, C 
Keywords: Chinese
Health-related quality of life
Hyperandrogenism
Metformin
Overweight
Polycystic ovary syndrome
Issue Date: 2016
Publisher: BioMed Central
Source: Health and quality of life outcomes, 2016, v. 14, no. 1, 119 How to cite?
Journal: Health and quality of life outcomes 
Abstract: Background: Few studies have assessed whether the amelioration of the clinical signs of polycystic ovary syndrome (PCOS) achieved by treatment leads to improvement in the health-related quality of life (HRQoL) of patients. This study was aimed to examine the HRQoL of ethnic Chinese women with PCOS who received metformin treatment.
Methods: This prospective study was conducted at a medical center in Taiwan. Study participants aged 18-45 years were diagnosed as having PCOS according to the Rotterdam criteria, and all received metformin treatment. Their HRQoL was assessed using generic (WHOQOL-Bref) and PCOS-specific (Chi-PCOSQ) instruments. Mixed effect models were used to examine the effects of metformin on repeatedly measured HRQoL. Additional analyses using stratified patients characteristics (overweight vs. normal; hyperandrogenism vs. non-hyperandrogenism) were done.
Results: We recruited 109 participants (56 % were overweight, 80 % had hyperandrogenism). Among the domain scores of WHOQOL-Bref, the psychological domain score was the lowest one (12.64±2.2, range 4-20). Weight (3.25±1.59, range 1-7) and infertility (3.38±1.93, range 1-7) domain scores were relatively low among the domain scores of Chi-PCOSQ. Overweight and hyperandrogenic patients had significantly lower HRQoL as compared with those of normal weight and non-hyperandrogenic patients, respectively. Metformin significantly improved the physical domain of WHOQOL-Bref (p=0.01), and the infertility (p=0.043) and acne and hair loss aspects (p=0.008) of PCOS-specific HRQoL. In the subgroup analysis, significantly improved HRQoL following metformin treatment appeared for only overweight and hyperandrogenism subgroups.
Conclusions: Metformin might improve health-related quality of life of polycystic ovary syndrome women by ameliorating psychological disturbances due to acne, hair loss and infertility problems, especially for overweight and hyperandrogenic patients.
URI: http://hdl.handle.net/10397/62162
EISSN: 1477-7525
DOI: 10.1186/s12955-016-0520-9
Rights: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
The following article: Ou, H. T., Chen, P. C., Wu, M. H., & Lin, C. Y. (2016). Metformin improved health-related quality of life in ethnic Chinese women with polycystic ovary syndrome. Health and quality of life outcomes, 14(1), 119, is available at https//doi.org/10.1186/s12955-016-0520-9
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Ou_Metformin_health-related_quality.pdf412.66 kBAdobe PDFView/Open
Access
View full-text via PolyU eLinks SFX Query
Show full item record
PIRA download icon_1.1View/Download Contents

SCOPUSTM   
Citations

9
Last Week
2
Last month
Citations as of Jun 18, 2018

WEB OF SCIENCETM
Citations

3
Last Week
0
Last month
Citations as of Jun 12, 2018

Page view(s)

67
Last Week
3
Last month
Citations as of Jun 18, 2018

Download(s)

2
Citations as of Jun 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.