Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/62032
Title: Total synthesis of teixobactin
Authors: Jin, K
Sam, IH
Po, KHL
Lin, D
Ghazvini, Zadeh, EH
Chen, S 
Yuan, Y
Li, X
Issue Date: 2016
Publisher: Nature Publishing Group
Source: Nature communications, 2016, v. 7 , 12394 How to cite?
Journal: Nature communications 
Abstract: To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.
URI: http://hdl.handle.net/10397/62032
EISSN: 2041-1723
DOI: 10.1038/ncomms12394
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