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Title: | Total synthesis of teixobactin | Authors: | Jin, K Sam, IH Po, KHL Lin, D Ghazvini, Zadeh, EH Chen, S Yuan, Y Li, X |
Issue Date: | 3-Aug-2016 | Source: | Nature communications, 3 Aug, 2016, v. 7, 12394, p.1-6 | Abstract: | To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product. | Publisher: | Nature Publishing Group | Journal: | Nature communications | EISSN: | 2041-1723 | DOI: | 10.1038/ncomms12394 | Rights: | This work is licensed under a Creative Commons Attribution 4.0International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,users will need to obtain permission from the license holder to reproduce the material.To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ © The Author(s) 2016 The following publication Jin, K.et al.Total synthesis of teixobactin.Nat. Commun.7:12394, 1-6 (2016) is available at https://dx.doi.org/10.1038/ncomms12394 |
Appears in Collections: | Journal/Magazine Article |
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