Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61922
Title: Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013-2014
Authors: Cao, P
Wong, CM
Chan, KH
Wang, X
Chan, KP
Peiris, JSM
Poon, LLM
Yang, L 
Issue Date: 2016
Source: Scientific reports, 25 2016, v. 6, no. , p. 1-8
Abstract: Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses.
Publisher: Nature Publishing Group
Journal: Scientific reports 
EISSN: 2045-2322
DOI: 10.1038/srep30260
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
© The Author(s) 2016
The following publication Cao, P., Wong, C., Chan, K. et al. Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014. Sci Rep 6, 30260 (2016) is available at https://dx.doi.org/10.1038/srep30260
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