Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/61629
Title: Purposeful activity in psychiatric rehabilitation : is neurogenesis a key player?
Authors: Cheung, JSC
Chan, JNM
Lau, BWM 
Ngai, SPC 
Keywords: Depression
Neurogenesis
Psychiatric conditions
Psychosocial intervention
Rehabilitation
Issue Date: 2016
Publisher: Elsevier
Source: Hong Kong journal of occupational therapy, 2016, v. 27, p. 42-47 How to cite?
Journal: Hong Kong journal of occupational therapy 
Abstract: Adult neurogenesis, defined as the generation of new neurons in adulthood, has been a fascinating discovery in neuroscience, as the continuously replenishing neuronal population provides a new perspective to understand neuroplasticity. Besides maintaining normal physiological function, neurogenesis also plays a key role in pathophysiology and symptomatology for psychiatric conditions. In the past decades, extensive effort has been spent on the understanding of the functional significance of neurogenesis in psychiatric conditions, mechanisms of pharmacological treatment, and discovery of novel drug candidates for different conditions. In a clinical situation, however, long-term rehabilitation treatment, in which occupational therapy is the key discipline, is a valuable, economical, and commonly used treatment alternative to psychotropic medications. Surprisingly, comparatively few studies have investigated the biological and neurogenic effects of different psychiatric rehabilitative treatments. To address the possible linkage between psychiatric rehabilitation and neurogenesis, this review discusses the role of neurogenesis in schizophrenia, major depression, and anxiety disorders. The review also discusses the potential neurogenic effect of currently used psychiatric rehabilitation treatments. With a better understanding of the biological effect of psychiatric rehabilitation methods and future translational studies, it is hoped that the therapeutic effect of psychiatric rehabilitation methods could be explained with a novel perspective. Furthermore, this knowledge will benefit future formulation of treatment methods, especially purposeful activities in occupational therapy, for the treatment of psychiatric disorders.
URI: http://hdl.handle.net/10397/61629
ISSN: 1569-1861
EISSN: 1876-4398
DOI: 10.1016/j.hkjot.2016.04.002
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