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Title: The multifocal on- and off-responses in the human diabetic retina
Authors: Lung, JCY 
Swann, PG 
Chan, HHL 
Issue Date: 2016
Publisher: Public Library of Science
Source: PLoS one, 2016, v. 11, no. 5, e0155071 How to cite?
Journal: PLoS one 
Abstract: The characteristics of the on- and off-responses in the human diabetic retina by a "longduration" multifocal electroretinogram (mfERG) paradigm were investigated. Changes in the retinal antagonistic interaction were also evaluated in the early stage of diabetes mellitus (DM). Twenty type II diabetic patients with no or mild non-proliferative diabetic retinopathy (NPDR) and twenty-one age-matched healthy controls were recruited for "long-duration" mfERG measurements. A 61-hexagon mfERG stimulus was displayed under two chromatic conditions (white/black and blue/black) at matched luminance. The amplitudes and implicit times of the on-response components (N1, P1 and N2) and off-response (P2) components were analysed. The blue stimulation generally triggered greater mfERG amplitudes in P1, N2 and P2 (p<0.05) than those from white stimulation in both control and diabetic groups. The diabetic group showed significantly greater N2 amplitude than the controls under white stimulation in mid-retinal regions (Rings 2 and 4) (p<0.05). When the stimulus was changed from white to blue, the diabetic group showed a smaller percentage change in N2 amplitude than the controls in peripheral retinal region (Ring 5) (p<0.02). When a stimulus is changed from white (broad-band spectral stimulation) to blue (narrow-band spectral stimulation), a decrease in the involvement of lateral antagonism would be expected. The larger amplitude of the on-response component (N2) in the diabetic patients suggested an imbalance of lateral antagonism, and the lesser percentage change of N2 amplitude in the diabetic group may indicate an impairment of the cross-talk at the middle retinal level in early stages of DM.
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0155071
Rights: © 2016 Lung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication Lung JCY, Swann PG, Chan HHL (2016) The Multifocal On- and Off-Responses in the Human Diabetic Retina. PLoS ONE 11(5): e0155071 is available at
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