Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/61403
Title: | Effects of lactobacillus plantarum TWK10-fermented soymilk on deoxycorticosterone acetate-salt-induced hypertension and associated dementia in rats | Authors: | Liu, TH Chiou, J Tsai, TY |
Issue Date: | 2016 | Source: | Nutrients, May 2016, v. 8, no. 5, p. 1-18 | Abstract: | Oxidative stress resulting from excessive production of reactive oxygen species is the major mediator of neuronal cell degeneration observed in neurodegenerative diseases, such as Alzheimer’s disease (AD) and vascular dementia (VaD). Additionally, hypertension has been shown to be a positive risk factor for VaD. Therefore, the objective of this study was to investigate the effects of Lactobacillus plantarum strain TWK10 (TWK10)-fermented soymilk on the protection of PC-12 cells in H2O2-, oxygen-glucose deprivation (OGD)- and deoxycorticosterone acetate (DOCA)-salt-induced rat models of VaD. Notably, the viabilities of H2O2-treated PC-12 cells and OGD model were significantly increased by treatment with TWK10-fermented soymilk ethanol extract (p < 0.05). In addition, oral administration of TWK10-fermented soymilk extract in DOCA-salt hypertension-induced VaD rats resulted in a significant decrease in blood pressure (p < 0.05), which was regulated by inhibiting ACE activity and promoting NO production, in addition to decreased escape latency and increased target crossing (p < 0.05). In conclusion, these results demonstrated that TWK10-fermented soymilk extract could improve learning and memory in DOCA-salt hypertension-induced VaD rats by acting as a blood pressure-lowering and neuroprotective agent. | Keywords: | Dementia Fermented soymilk Hypertension Neuronal cell degeneration Reactive oxygen species |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | Nutrients | ISSN: | 2072-6643 | DOI: | 10.3390/nu8050260 | Rights: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). The following publication Liu, T. H., Chiou, J., & Tsai, T. Y. (2016). Effects of lactobacillus plantarum TWK10-fermented soymilk on deoxycorticosterone acetate-salt-induced hypertension and associated dementia in rats. Nutrients, 8(5), (Suppl. ), - is available athttps://dx.doi.org/10.3390/nu8050260 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Liu_Lactobacillus_Plantarum_TWK10-fermented.pdf | 1.77 MB | Adobe PDF | View/Open |
Page views
121
Last Week
1
1
Last month
Citations as of Apr 28, 2024
Downloads
48
Citations as of Apr 28, 2024
SCOPUSTM
Citations
31
Last Week
0
0
Last month
Citations as of May 3, 2024
WEB OF SCIENCETM
Citations
51
Last Week
0
0
Last month
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.