Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/609
Title: | Modified β-lactamases and uses thereof | Authors: | Wong, KY Leung, TYC Chan, PH |
Issue Date: | 29-Jan-2008 | Source: | US Patent 7,323,303 B2. Washington, DC: US Patent and Trademark Office, 2008. | Abstract: | A tool that can screen bacteria for β-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into β-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair the binding affinity of the protein to a great extent to provide a higher sensitivity. A modified β-lactamases with a residue on the Ω-loop or outside the Ω-loop but close to the active site of β-lactamase being replaced by a reactive residue is developed in this invention. | Keywords: | β-lactamases | Rights: | Assignee: The Hong Kong Polytechnic University. |
Appears in Collections: | Patent |
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us7323303b2.pdf | 1.15 MB | Adobe PDF | View/Open |
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