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Title: Design, synthesis of 4-hydroxyl-α-cyanocinnmaic acid derived compounds and their applications in chiral recognition of amino acids by mass spectrometry
Other Title: 4-羟基-α-氰基肉桂酸衍生物的设计合成及在质谱法手性识别氨基酸中的应用 (英文)
Authors: Luo, XY
Wang, HX
Zhang, S
Chen, P
Zheng, HH
Chen, HR
Yao, ZP 
Issue Date: 2013
Source: 暨南大学学报. 自然科学与医学版 (Journal of Jinan University. Natural science & medicine edition), Feb. 2013, v. 34, no. 1, p. 106-114
Abstract: 设计合成了4对以脯氨酸和4-羟基-α-氰基肉桂酸(CHCA)为骨架、作为手性选择子的化合物。通过ESI-MS/MS质谱方法研究氨基酸与手性识别子所形成的质子化二聚体和三聚体,评估了这些化合物对19种氨基酸的手性识别作用。探讨了手性识别子结构变化对氨基酸手性识别作用的影响。
Four pairs of compounds designed based on scaffolds of proline and 4-hydroxy-α-cyanocynnmaic acid(CHCA) have been synthesized as the chiral selectors.Chiral recognition of these compounds towards 19 common amino acids was evaluated by investigating the ESI-MS / MS spectra of the protonated dimers and trimers formed between the amino acids and the chiral selectors.Effects of the structural change of the chiral selectors on chiral recognition towards the amino acids were discussed in this study.
Keywords: Chiral recognition
Mass spectrometry
Amino acid
Proline 4-hydroxy-α-cyanocynnmaic acid
Publisher: 曁南大學
Journal: 暨南大学学报. 自然科学与医学版 (Journal of Jinan University. Natural science & medicine edition) 
ISSN: 1000-9965
Rights: © 2013 中国学术期刊电子杂志出版社。本内容的使用仅限于教育、科研之目的。
© 2013 China Academic Journal Electronic Publishing House. It is to be used strictly for educational and research purposes.
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